Key result
Sedentary lifestyle linked to ~110% higher risk of acute CHD in women.
Why the study?
Relatively few studies have assessed the prospective relationship of sedentary lifestyle and coronary heart disease in women.
Does a sedentary lifestyle increase the risk of acute coronary heart disease in women?
Case-Control (n=200)
Does a sedentary lifestyle increase the risk of acute coronary heart disease in women?
Odds Ratio: 2.1 (95% CI 1–4.3)
p-value: p=0.046
A sedentary lifestyle is associated with an approximately twofold increased risk of acute coronary heart disease in women, independent of other traditional risk factors.
Hypothesis-generating for sedentary lifestyle as CHD risk factor in women; prospective studies needed before clinical adoption.
EATON, C. B., K. L. LAPANE, C. A. GARBER, A. R. ASSAF, T. M. LASATER, and R. A. CARLETON. Sedentary lifestyle and risk of coronary heart disease in women. Med. Sci. Sports Exerc., Vol. 27, No. 11, pp. 1535–1539, 1995. Relatively few studies have assessed the prospective relationship of sedentary lifestyle and coronary heart disease (CHD) in women. We performed a nested case-control study, identifying 50 cases of acute CHD in women and 150 age-matched controls. Risk factors including sedentary lifestyle, cigarette smoking, hypertension, diabetes mellitus, total, and HDL cholesterol levels had been previously determined in this cohort using household survey techniques. The odds ratio (OR) of CHD in sedentary women was 2.1 (95% CI 1.0–4.3, P = 0.046). The odds ratio was similar (OR = 2.3, 95% CI 1.0–5.7, P = 0.051) after adjusting for potential confounders of hypertension, cigarette smoking, low HDL cholesterol, diabetes mellitus, and being U.S. born. This study suggests that sedentary lifestyle may be an independent risk factor for CHD in women, but its results are open to several contradictory interpretations. Further studies to investigate the prospective relationship of sedentary lifestyle and the risk of CHD in women are needed.
No takes yet. Share an insight, caveat, or question.
Eaton et al. (1995) conducted a case-control in coronary heart disease (n=200). Sedentary lifestyle vs. Non-sedentary lifestyle was evaluated on acute coronary heart disease (OR 2.1, 95% CI 1.0-4.3, p=0.046). A sedentary lifestyle was associated with an increased risk of acute coronary heart disease in women (OR 2.1; 95% CI 1.0-4.3; P=0.046).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: