Key result
Higher early post-transplant TnI levels positively correlate with inotropic drug requirements.
Why the study?
The correlation between postoperative troponin I concentration and hemodynamic function after heart transplantation was not well defined.
Observational (n=54)
No
Effect estimate: r = 0.51
p-value: p=0.00
Postoperative plasma troponin I levels correlate with hemodynamic parameters and inotropic requirements, suggesting its utility as a marker for assessing early hemodynamic function after heart transplantation.
Post-HTX TnI levels correlated with hemodynamic impairment; leaves open whether serial monitoring improves graft management in transplant recipients.
INTRODUCTION: Plasma troponin I (TnI) concentration is a well-established and widely-used marker of myocardial damage. AIM: To determine the correlation between TnI concentration measured within the first 4 days following heart transplantation (HTX) and clinical course, with consideration of hemodynamic performance. MATERIAL AND METHODS: The retrospective study included 54 patients (12-62 years) who underwent HTX. TnI levels were assessed over the first 4 post-operative days. Hemodynamic parameters were assessed daily at Swan-Ganz catheterization and echocardiography. The number of required inotropic drugs was also analyzed. RESULTS: There is a strong and positive correlation between the mean TnI levels and the mean number of required inotropic drugs (r = 0.51, p = 0.00), and also mean central venous pressure (CVP) (r = 0.33, p = 0.015). A weak trend towards a positive correlation between the mean values of pulmonary capillary wedge pressure (PCWP) and the mean plasma TnI levels was observed. There was no correlation between mean TnI levels and mean values of ejection fraction (EF) and cardiac output (CO). Detailed analysis showed a statistically significant correlation between TnI levels on days 3 and 4 after HTX and PCWP on the preceding days (r = 0.32, p = 0.04; r = 0.46, p = 0.006 respectively). Furthermore, a strong, inverse correlation between TnI levels on day 3 and CO on day 4 following HTX was observed (r = -0.44, p = 0.03). CONCLUSIONS: Plasma TnI could be a useful marker for assessing the hemodynamic function after HTX.
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Wierzbicki et al. (2014) conducted an observational in Heart transplantation (n=54). Plasma troponin I (TnI) concentration was evaluated on Correlation between mean plasma TnI levels and mean number of required inotropic drugs (r = 0.51, p=0.00). Mean plasma troponin I levels measured over the first 4 days after heart transplantation positively correlated with the mean number of required inotropic drugs (r = 0.51, p = 0.00).
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