Why the study?
Despite advances in therapies and public health, the joint mortality burden of obesity and hypertension in the U.S. remains substantial and requires characterization of national trends and disparities.
Population
254,116 obesity- and hypertension-related deaths in U.S. adults aged ≥ 25 years from 2000 to 2019
Comparison
Mortality trends stratified by sex, race/ethnicity, urban-rural classification, and U.S. Census region
Design
Retrospective descriptive study using CDC WONDER multiple cause-of-death data
Follow-up
20 years
Key result
The combined age-adjusted mortality rate for obesity and hypertension in the U.S. increased significantly from 2.58 to 9.62 per 100,000 population between 2000 and 2019 (AAPC 7.31).
Authors
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Rising combined mortality with sex, racial, and rural disparities signals urgent prevention needs; observational trends leave open optimal intervention targets.
Observational (n=254,116)
Effect estimate: AAPC 7.31 (95% CI 6.66-7.97)
Absolute Event Rate: 9.62% vs 2.58%
p-value: p=<0.05
Obesity- and hypertension-related mortality in U.S. adults increased significantly from 2000 to 2019, highlighting a growing public health crisis with pronounced demographic and geographic disparities.
Nabi et al. (2025) conducted an observational in Obesity and hypertension-related mortality (n=254,116). Obesity and hypertension vs. Year 2000 was evaluated on Age-Adjusted Mortality Rate (AAMR) per 100,000 population (AAPC 7.31, 95% CI 6.66-7.97, p=<0.05). The combined age-adjusted mortality rate for obesity and hypertension in the U.S. increased significantly from 2.58 to 9.62 per 100,000 population between 2000 and 2019 (AAPC 7.31).
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