Key result
Cardiac troponins T and I serve as sensitive and specific markers for detecting chemotherapy-induced cardiotoxicity.
Why the study?
Chemotherapy can cause reversible and/or irreversible cardiotoxicity, necessitating study of cardiac troponins as sensitive and specific markers for myocardium damage in oncology patients.
Does cardiac troponin screening effectively reveal cardiotoxicity in oncology patients receiving chemotherapy?
Does cardiac troponin screening effectively reveal cardiotoxicity in oncology patients receiving chemotherapy?
This review highlights the importance of using cardiac troponins T and I as sensitive and specific markers for the early detection of chemotherapy-induced cardiotoxicity in oncology patients.
Answers are grounded in this paper and cite their sources.
May support troponin monitoring in chemotherapy patients; leaves open need for prospective validation before routine adoption.
Recently, chemotherapy is one of the most trustworthy methods for treatment of malignant tumors and blood pathology. However clinical effect of the drugs not always matches with safety. These facts play as a solid evidence for the necessity of studying the problems related to side effects of the drugs, and, particularly, of cardiotoxicity, as reversible and/or irreversible damage of cardiomyocytes. Currently, the most sensitive ad specific markers of myocardium cells are troponins T and I. According with this, the main aims of this article are analysis of literary data for the problem of cardiac troponins application as cardiotoxicity revealing in oncology patients, and summon of more attention to this direction of science. The article provides a collection of the key points of all available studies at the moment, shows generalized analysis, analyses also the Russian and European Guidelines from the point of view related to troponins tests in oncology patients.
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Krikunova et al. (2015) conducted a review in Oncology patients undergoing chemotherapy. Cardiac troponins T and I was evaluated on Chemotherapy-induced cardiotoxicity. Cardiac troponins T and I serve as sensitive and specific markers for detecting chemotherapy-induced cardiotoxicity in oncology patients based on a review of current literature and guidelines.
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