Key result
Salvia miltiorrhiza extract restores heart function in heart failure rats via SDF-1/CXCR4 and Bcl-2 pathways.
Why the study?
There was no study on the cardioprotective effects of Salvia miltiorrhiza against heart failure and the underlying mechanisms involving the SDF-1/CXCR4 axis were poorly understood.
Does aqueous extract of Salvia miltiorrhiza improve heart function and myocardial pathology in heart failure rats?
Does aqueous extract of Salvia miltiorrhiza improve heart function and myocardial pathology in heart failure rats?
In a rat model of heart failure, aqueous extract of Salvia miltiorrhiza improved heart function and myocardial pathology, potentially via the SDF-1/CXCR4 axis and Bcl-2 family expressions.
May support AESM development in HF models; hypothesis-generating, should not change practice pending human trials.
Salvia Miltiorrhizae Bge, a popular Chinese herb has been widely adopted for use in Chinese hospitals for both the prevention and the active management of cardiovascular disease. there is no study on its cardioprotective effects against HF and more importantly, the underlying mechanisms of its beneficial effects by SDF-1/CXCR4 axis remain poorly understood. This study was performed to investigate the protective effects and possible mechanism of aqueous extract of Salvia miltiorrhiza (AESM) on HF rats. In the study, cardioprotective effects of AESM on HF rats was evaluated by herat function, myocardial pathology, myocardial cell proliferation, SDF-1, CXCR4 and Bcl-2 family mRNA expressions. In the experiment, we found that AESM exerted beneficially protective effects on the HF rats, mainly recoverying normal heart function, myocardial pathology and myocardial cell proliferation. The underlying mechanism of these protective effects of AESM appeared to involve improving the SDF-1/CXCR4 axis and Bcl-2 family expressions.
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Zhang et al. (2014) studied Heart Failure. Aqueous extract of Salvia miltiorrhiza (AESM) was evaluated on Heart function, myocardial pathology, myocardial cell proliferation, SDF-1, CXCR4 and Bcl-2 family mRNA expressions. Aqueous extract of Salvia miltiorrhiza exerted beneficial protective effects on heart failure rats by recovering normal heart function and improving SDF-1/CXCR4 axis and Bcl-2 family expressions.
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