Key result
HDL, male sex, BMI, and smoking are associated with ~28% of endothelial function variability.
Why the study?
The association between lowered endothelial function measured by peripheral arterial tonometry and cardio-metabolic risk factors in individuals at risk of diabetes or cardiovascular disease was not well defined.
Population
312 middle-aged Finnish municipal workers at risk of diabetes or cardiovascular disease
Comparison
Groups defined by levels of cardio-metabolic risk factors and endothelial function
Design
Cross-sectional study
Authors
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Lowered PAT endothelial function associated with HDL, BMI and smoking in at-risk workers; leaves open its added value for risk prediction.
Cross-Sectional (n=312)
No
Effect estimate: R2 0.283
p-value: p=<0.0001
Endothelial dysfunction measured by peripheral arterial tonometry is significantly associated with traditional cardio-metabolic risk factors including low HDL, male sex, higher BMI, and smoking.
Konttinen et al. (2013) conducted a cross-sectional in At risk of diabetes and cardiovascular disease (n=312). Cardio-metabolic risk factors (HDL cholesterol, male sex, BMI, smoking) vs. Absence of risk factors or lower levels was evaluated on Endothelial function measured by Framingham reactive hyperemia index (F-RHI) (R2 0.283, p=<0.0001). HDL cholesterol, male sex, body mass index, and current smoking were significantly associated with endothelial function (F-RHI), explaining 28.3% of its variability in municipal workers.
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