June 6, 2020European Heart Journal - Cardiovascular Imaging
Echocardiographic predictors of cardiovascular morbidity and mortality in women from the general population
Key result
Higher LVMI and lower e' linked to increased risk of major cardiovascular events in women.
- HR 1.10
- 95% CI 1.03-1.17
- P=0.004
- n=1,245
Why the study?
GLS may not predict cardiovascular outcomes as effectively in women, necessitating identification of echocardiographic predictors of cardiovascular morbidity and mortality in women from the general population.
Do echocardiographic parameters such as LVMI and e' predict cardiovascular morbidity and mortality in women from the general population?
Population
1245 women from the general population free of HF and atrial fibrillation
Comparison
Echocardiographic parameters including LVMI, e', and GLS
Design
Cohort study
Follow-up
Median 12.5 years
Authors
Discussion
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Implication
These markers may refine CV risk stratification in women; leaves open whether they guide therapy or improve outcomes.
Study Design
Type
Cohort (n=1,245)
Structured PICO
Do echocardiographic parameters such as LVMI and e' predict cardiovascular morbidity and mortality in women from the general population?
P
Population
1,245 women from the general population free of heart failure and atrial fibrillation, followed for a median of 12.5 years.
E
Exposure
Echocardiographic examination including tissue Doppler imaging and strain analysis (assessing parameters such as LVMI, e', and GLS)
O
Outcome
Composite of acute myocardial infarction, heart failure, and cardiovascular deathcomposite
Main Result
Hazard Ratio: 1.1 (95% CI 1.03–1.17)
p-value: p=0.004
In women from the general population, left ventricular mass index and diastolic dysfunction (e'), but not global longitudinal strain, are independent predictors of adverse cardiovascular outcomes.
Cite This Study
Lundorff et al. (2020) conducted a cohort in general population (n=1,245). Left ventricular mass index (LVMI) and e' was evaluated on composite of acute myocardial infarction, HF, and cardiovascular death (HR 1.10, 95% CI 1.03-1.17, p=0.004). Higher left ventricular mass index (HR 1.10; 95% CI 1.03-1.17) and lower e' (HR 1.53; 95% CI 1.07-2.20) independently predicted acute MI, heart failure, or cardiovascular death in women.