Key result
Bilateral adrenalectomy abolishes epinephrine response and tends to lower resuscitation rates in experimental cardiac arrest.
Why the study?
The plasma catecholamine and serum cortisol responses to cardiac arrest, CPR, and defibrillation and the role of the adrenal medullas in these responses were not fully characterized.
Does bilateral adrenalectomy alter the catecholamine response and resuscitation success during experimental cardiac arrest in dogs?
Does bilateral adrenalectomy alter the catecholamine response and resuscitation success during experimental cardiac arrest in dogs?
Absolute Event Rate: 10% vs 60%
p-value: p=>0.05 <0.1
The adrenal medullas are the predominant source of the massive epinephrine response during cardiac arrest, which may contribute to resuscitation success.
No takes yet. Share an insight, caveat, or question.
Adrenalectomy abolishes epinephrine response in canine arrest; hypothesis-generating for adrenal role in resuscitation, needs human validation.
Foley et al. (1987) studied Experimental cardiac arrest (n=20). Bilateral adrenalectomy vs. Sham-operated controls (intact) was evaluated on Resuscitation from experimental cardiac arrest (p=>0.05 <0.1). Bilateral adrenalectomy in dogs undergoing experimental cardiac arrest resulted in a virtually nonexistent epinephrine response and tended to lower resuscitation rates (10% vs 60%, P>0.05 to <0.1).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: