Key result
HLHS is linked to ~260% greater risk of late adverse events in ECC Fontan recipients.
Why the study?
Factors associated with hospital and long-term outcomes after extracardiac conduit Fontan procedure were not well defined in a large binational cohort.
Population
570 patients undergoing extracardiac conduit Fontan procedure in Australia and New Zealand
Comparison
Patients with hypoplastic left heart syndrome versus other morphological groups
Design
Binational cohort study
Follow-up
Mean 6.7 years
Authors
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May warrant intensified surveillance in HLHS patients after ECC Fontan; leaves open optimal risk-stratification strategies.
Cohort (n=570)
Yes
Hazard Ratio: 3.6 (95% CI 1.3–7.5)
The extracardiac Fontan procedure provides excellent long-term survival, though patients with hypoplastic left heart syndrome are at higher risk for late adverse events.
Iyengar et al. (2014) conducted a cohort in Extracardiac conduit Fontan recipients (n=570). Hypoplastic left heart syndrome (HLHS) vs. Other morphological groups was evaluated on Adverse events (HR 3.6, 95% CI 1.3-7.5). Hypoplastic left heart syndrome was strongly associated with an increased risk of late adverse events (HR 3.6; 95% CI 1.3-7.5) and late failure (HR 2.8; 95% CI 1.1-7.5) in ECC Fontan recipients.
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