Key result
Lifestyle modification linked to ~64% fewer vascular 18F-FDG-positive lesions, correlating with increased HDL.
Why the study?
Whether vascular inflammation measured by 18F-FDG uptake can be reversed by atherogenic risk-modifying lifestyle interventions has not been demonstrated.
Does lifestyle modification reduce vascular 18F-FDG uptake in healthy adults?
Population
60 healthy adults
Comparison
Baseline vs after lifestyle modification
Design
Observational cohort study with serial PET/CT scans
Follow-up
17.1 +/- 8.3 months
Authors
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Supports potential anti-inflammatory benefit of lifestyle modification; hypothesis-generating and requires randomized confirmation before practice change.
Observational (n=60)
Does lifestyle modification reduce vascular 18F-FDG uptake in healthy adults?
Absolute Event Rate: 2.1% vs 5.9%
p-value: p=<0.0001
Lifestyle modification reduces vascular inflammation as measured by 18F-FDG PET/CT, and the magnitude of this reduction correlates with increases in plasma HDL levels.
Lee et al. (2008) conducted an observational in Atherosclerotic inflammation (n=60). Lifestyle modification vs. Baseline was evaluated on Vascular 18F-FDG-positive lesions per subject (p=<0.0001). Lifestyle modification over 17 months significantly reduced vascular 18F-FDG-positive lesions from 5.9 to 2.1 sites per subject (P < 0.0001), with the reduction correlating to increased HDL levels.
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