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September 20, 1995JAMA

Changes in Myocardial Perfusion Abnormalities by Positron Emission Tomography After Long-term, Intense Risk Factor Modification

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Why the study?

Does intense risk factor modification improve myocardial perfusion abnormalities measured by PET in patients with coronary artery disease?

Population

35 patients with coronary artery disease

Comparison

Intense risk factor modification consisting of… vs Usual care by their own physicians, consisting…

Design

RCT, Randomization of patients

Follow-up

5 years

Authors

KGK. Lance GouldCardiac Imaging

Discussion

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Overview

Supports intensive risk factor modification in CAD; extends evidence to quantitative PET perfusion endpoints.

Structured PICO

Does intense risk factor modification improve myocardial perfusion abnormalities measured by PET in patients with coronary artery disease?

P
Population
35 patients with coronary artery disease
I
Intervention
Intense risk factor modification consisting of very low-fat vegetarian diet, mild to moderate exercise, stress management, and group support for 5 years
C
Comparator
Usual care by their own physicians, consisting principally of antianginal therapy
O
Outcome
Changes in size and severity of myocardial perfusion abnormalities on rest-dipyridamole PET images and stenosis severity on arteriograms at 5 yearssurrogate

Intense risk factor modification over 5 years significantly improves myocardial perfusion abnormalities on PET imaging compared to usual care in patients with coronary artery disease.

Cite This Study

K. Lance Gould (1995) studied this question.

synapsesocial.com/papers/6a1dd163ef3fa0b4c0ef6bfbhttps://doi.org/10.1001/jama.1995.03530110056036

Topics

Coronary CT angiography
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