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September 20, 1995JAMA

Changes in myocardial perfusion abnormalities by positron emission tomography after long-term, intense risk factor modification

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Why the study?

Does intense risk factor modification improve myocardial perfusion abnormalities on PET in patients with coronary artery disease?

Population

35 patients with coronary artery disease (n=35)

Comparison

Intense risk factor modification consisting of… vs Usual care by their own physicians, consisting…

Design

RCT, Randomized

Follow-up

5 years

Authors

KGK. Lance GouldCardiac Imaging

Discussion

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Overview

Supports intensive risk factor modification in CAD; extends prior data with RCT confirmation of PET perfusion benefit.

Structured PICO

Does intense risk factor modification improve myocardial perfusion abnormalities on PET in patients with coronary artery disease?

P
Population
35 patients with coronary artery disease (n=35)
I
Intervention
Intense risk factor modification consisting of very low-fat vegetarian diet, mild to moderate exercise, stress management, and group support for 5 years
C
Comparator
Usual care by their own physicians, consisting principally of antianginal therapy
O
Outcome
Changes in size and severity of myocardial perfusion abnormalities on rest-dipyridamole PET images and stenosis severity on arteriograms at 5 yearssurrogate

Intense lifestyle and risk factor modification over 5 years leads to measurable improvements in myocardial perfusion on PET imaging in patients with coronary artery disease.

Cite This Study

K. Lance Gould (1995) studied this question.

synapsesocial.com/papers/6a8830a4d79ae02bd34dfcf7https://doi.org/10.1001/jama.274.11.894
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in Myocardial Perfusion Abnormalities by Positron Emission Tomography After Long-term, Intense Risk Factor Modification1995 · 271 citations
  2. 2Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease. A potential noninvasive marker of healing coronary endothelium.1994 · 337 citations
  3. 3Frequency and Clinical Implications of Fluid Dynamically Significant Diffuse Coronary Artery Disease Manifest as Graded, Longitudinal, Base-to-Apex Myocardial Perfusion Abnormalities by Noninvasive Positron Emission Tomography2000 · 197 citations
  4. 4The clinical importance of risk factor modification: Looking at both myocardial viability (MV) and myocardial perfusion imaging (MPI)2005 · 10 citations
  5. 5Electrocardiographic changes after dipyridamole infusion in patients undergoing myocardial perfusion imaging2010 · 4 citations