What question did this study set out to answer?

To determine whether diffuse coronary artery narrowing manifests as a graded, longitudinal, base-to-apex myocardial perfusion gradient on noninvasive PET imaging in patients with mild coronary artery disease.

April 25, 2000CirculationOpen Access

Frequency and Clinical Implications of Fluid Dynamically Significant Diffuse Coronary Artery Disease Manifest as Graded, Longitudinal, Base-to-Apex Myocardial Perfusion Abnormalities by Noninvasive Positron Emission Tomography

View Full Paper

Ask AI

Bookmark

Authors

KGK. Lance GouldCardiac Imaging YNYuko NakagawaGunma University KNKeiichi NakagawaPrecision Research (United States)

Discussion

Member takes

Overview

Observational study reveals longitudinal base-to-apex PET perfusion abnormalities in patients with coronary disease, indicating widespread diffuse narrowing even without localized defects.

Key Points

To determine whether diffuse coronary artery narrowing manifests as a graded, longitudinal, base-to-apex myocardial perfusion gradient on noninvasive PET imaging in patients with mild coronary artery disease.
Assessed 1,001 patients with arteriographically documented coronary artery disease who underwent rest-dipyridamole PET perfusion imaging.
Quantified circumscribed segmental perfusion defects and graded longitudinal base-to-apex perfusion gradients using automated software measuring the spatial slope of relative activity.
Patients with mild arteriographic disease without segmental perfusion defects demonstrated a significant base-to-apex perfusion gradient compared with normal controls (P=0.001), which was also present in moderate-to-severe segmental defects (P=0.0001).
Overall, 43% of patients with or without segmental perfusion defects exhibited longitudinal base-to-apex perfusion abnormalities exceeding ±2 SD of normal control subjects.

Cite This Study

Gould et al. (2000) studied this question.

synapsesocial.com/papers/6a830b43c0477142e551aa5a https://doi.org/10.1161/01.cir.101.16.1931

View Full Paper

Ask AI

Bookmark

April 25, 2000CirculationOpen Access

Frequency and Clinical Implications of Fluid Dynamically Significant Diffuse Coronary Artery Disease Manifest as Graded, Longitudinal, Base-to-Apex Myocardial Perfusion Abnormalities by Noninvasive Positron Emission Tomography

View Full Paper

Ask AI

Bookmark

Authors

KGK. Lance GouldCardiac Imaging YNYuko NakagawaGunma University KNKeiichi NakagawaPrecision Research (United States)

Discussion

Member takes

Overview

Observational study reveals longitudinal base-to-apex PET perfusion abnormalities in patients with coronary disease, indicating widespread diffuse narrowing even without localized defects.

Key Points

To determine whether diffuse coronary artery narrowing manifests as a graded, longitudinal, base-to-apex myocardial perfusion gradient on noninvasive PET imaging in patients with mild coronary artery disease.
Assessed 1,001 patients with arteriographically documented coronary artery disease who underwent rest-dipyridamole PET perfusion imaging.
Quantified circumscribed segmental perfusion defects and graded longitudinal base-to-apex perfusion gradients using automated software measuring the spatial slope of relative activity.
Patients with mild arteriographic disease without segmental perfusion defects demonstrated a significant base-to-apex perfusion gradient compared with normal controls (P=0.001), which was also present in moderate-to-severe segmental defects (P=0.0001).
Overall, 43% of patients with or without segmental perfusion defects exhibited longitudinal base-to-apex perfusion abnormalities exceeding ±2 SD of normal control subjects.

Cite This Study

Gould et al. (2000) studied this question.

synapsesocial.com/papers/6a830b43c0477142e551aa5a https://doi.org/10.1161/01.cir.101.16.1931

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark