Key result
BK channels open and close in two steps via a brief subconductance state.
Why the study?
The detailed mechanisms of opening and closing transitions of large-conductance calcium-activated K+ channels at microsecond resolution were not fully understood.
Population
Large-conductance calcium-activated K+ (BK) channels
Comparison
Opening versus closing transitions of BK channels
Design
Single channel current recordings with microsecond time resolution
Authors
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Challenges binary gating models for BK channels; leaves open any cardiovascular relevance pending further validation.
Opening and closing transitions of BK channels often occur in two steps via brief subconductance states.
Ferguson et al. (1993) studied this question. Single channel currents from large-conductance calcium-activated K+ channels was evaluated on Opening and closing transitions. Analysis of single channel currents from BK channels revealed that opening and closing transitions often occur in two steps via a brief lifetime subconductance state.
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