What question did this study set out to answer?

Synthesize current evidence on emerging biological therapies that target the interconnected hallmarks of aging, including chronic inflammation, cellular senescence, and regenerative decline.

September 17, 2026Stem Cell Research & TherapyOpen Access

Emerging biological therapies for healthy aging: targeting inflammaging, senescence, and regenerative decline

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Authors

MKMuhammad Shafique Khan MLMengyu Liu ASAymen SafdarGovernment College University, Lahore

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Overview

Scientific review highlights biological therapies targeting inflammaging and senescence, indicating multi-target potential to delay age-related decline.

Key Points

Synthesize current evidence on emerging biological therapies that target the interconnected hallmarks of aging, including chronic inflammation, cellular senescence, and regenerative decline.
Reviewed preclinical and early clinical literature on biological interventions, including mesenchymal stem cell therapies, stem cell-derived extracellular vesicles, monoclonal antibodies, and plasma-based approaches.
Evaluated translational barriers spanning biological safety, manufacturing standardization, scalability, and long-term therapeutic efficacy.
Emerging biological therapies exhibit broad pleiotropic activity across systemic inflammatory, metabolic, and regenerative networks rather than one-to-one actions on isolated aging hallmarks.
Early-phase findings demonstrate benefits in immunomodulation, cell-free matrix remodeling, and precision inflammatory control, though clinical translation requires standardized validation protocols.

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/6aabb61e5f706d05830e4921 https://doi.org/10.1186/s13287-026-05287-9

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September 17, 2026Stem Cell Research & TherapyOpen Access

Emerging biological therapies for healthy aging: targeting inflammaging, senescence, and regenerative decline

View Full Paper

Ask AI

Bookmark

Authors

MKMuhammad Shafique Khan MLMengyu Liu ASAymen SafdarGovernment College University, Lahore

Discussion

Member takes

Overview

Scientific review highlights biological therapies targeting inflammaging and senescence, indicating multi-target potential to delay age-related decline.

Key Points

Synthesize current evidence on emerging biological therapies that target the interconnected hallmarks of aging, including chronic inflammation, cellular senescence, and regenerative decline.
Reviewed preclinical and early clinical literature on biological interventions, including mesenchymal stem cell therapies, stem cell-derived extracellular vesicles, monoclonal antibodies, and plasma-based approaches.
Evaluated translational barriers spanning biological safety, manufacturing standardization, scalability, and long-term therapeutic efficacy.
Emerging biological therapies exhibit broad pleiotropic activity across systemic inflammatory, metabolic, and regenerative networks rather than one-to-one actions on isolated aging hallmarks.
Early-phase findings demonstrate benefits in immunomodulation, cell-free matrix remodeling, and precision inflammatory control, though clinical translation requires standardized validation protocols.

Cite This Study

Khan et al. (2026) studied this question.

synapsesocial.com/papers/6aabb61e5f706d05830e4921 https://doi.org/10.1186/s13287-026-05287-9

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