Key result
Higher adiposity and lower physical activity linked to increased prediabetes risk among CAYA cancer survivors.
Why the study?
Survivors of childhood, adolescent, and young adult cancer and hematopoietic cell transplantation have an excess risk of prediabetes and cardiovascular disease that is not well characterized in relation to body composition and physical activity.
Are body composition and physical activity associated with prediabetes in childhood, adolescent, and young adult cancer and hematopoietic cell transplantation survivors?
Case-Control (n=100)
Are body composition and physical activity associated with prediabetes in childhood, adolescent, and young adult cancer and hematopoietic cell transplantation survivors?
Answers are grounded in this paper and cite their sources.
Higher body mass index, central adiposity, and lower physical activity are associated with prediabetes in CAYA cancer survivors, identifying modifiable targets to reduce cardiometabolic risk.
Survivors of childhood, adolescent, and young adult (CAYA) cancer and hematopoietic cell transplantation have an excess risk of prediabetes and cardiovascular disease. Though not well characterized among CAYA survivors, cancer-directed therapies may alter body composition and metabolic health, potentially contributing to this risk. We evaluated body composition and physical activity among 100 long-term CAYA survivors (40 with prediabetes; 60 controls without prediabetes/diabetes). Survivors with prediabetes reported lower physical activity and had greater central adiposity than controls. Higher body mass index, visceral adipose tissue index, waist circumference, and fat mass were associated with increased odds of prediabetes. These findings identify potentially modifiable targets of cardiometabolic vulnerability among CAYA survivors.
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Bhandari et al. (2026) conducted a case-control in Childhood, adolescent, and young adult cancer and hematopoietic cell transplantation survivors (n=100). Body composition and physical activity was evaluated on Prediabetes. Higher body mass index, visceral adipose tissue index, waist circumference, fat mass, and lower physical activity were associated with increased odds of prediabetes among CAYA cancer survivors.
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