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September 12, 2026Journal of BiotechnologyOpen Access

Enhancing extracellular vesicles purity from plasma: A comparative study of isolation strategies

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Authors

ESEsther Serrano‐PertierraEÁElena Sánchez ÁlvarezMBMa Carmen Blanco-López

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Overview

Comparative study demonstrates that pairing size exclusion chromatography with precipitation maximizes extracellular vesicle purity from plasma, indicating suitability for biomarker discovery.

Key Points

  • To evaluate whether combining distinct isolation workflows improves the purity and yield of extracellular vesicles derived from plasma for biomarker analysis.
  • Compared two sequential isolation strategies: ultracentrifugation followed by precipitation and size exclusion chromatography followed by precipitation (using ExoQuick-TC).
  • Characterized isolated extracellular vesicles by evaluating particle size distribution, total lipid content, and protein purity.
  • Coupling size exclusion chromatography with ExoQuick-TC precipitation preserved extracellular vesicle integrity and produced high sample purity.
  • Ultracentrifugation coupled with precipitation resulted in reduced vesicle recovery and required larger initial plasma volumes, limiting its clinical feasibility.

Cite This Study

Serrano‐Pertierra et al. (2026) studied this question.

synapsesocial.com/papers/6aabc53fef52b0402e16e245https://doi.org/10.1016/j.jbiotec.2026.09.006
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