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July 1, 2001Cardiology in the Young

Cardiopulmonary exercise performance in adult survivors of the Mustard procedure

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Key result

Adult Mustard survivors exhibit subnormal exercise capacity and lower maximum oxygen uptake versus healthy controls.

  • n=84

Why the study?

There have been few reports on resting and exercise hemodynamics in a large population of adults with the Mustard procedure.

Does prior Mustard procedure reduce cardiopulmonary exercise performance in adult survivors compared to a healthy population?

Population

84 adults with the Mustard procedure who underwent cardiopulmonary exercise tests

Comparison

Adults with Mustard procedure vs healthy population controls

Design

Observational cross-sectional study

Authors

SHSloane HechterMount Sinai HospitalGWGary D. WebbAdult Congenital Heart DiseasePFPer Morten FredriksenØstfold University College

Discussion

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Implication

Characterizes adult Mustard hemodynamics; leaves open prognostic value and need for prospective outcome studies.

Study Design

Type

Observational (n=84)

Multicenter

No

Structured PICO

Does prior Mustard procedure reduce cardiopulmonary exercise performance in adult survivors compared to a healthy population?

P
Population
84 adult survivors of the Mustard procedure who underwent cardiopulmonary exercise testing to assess resting and exercise hemodynamics.
E
Exposure
Prior Mustard procedure
C
Comparator
Healthy population controls
O
Outcome
Cardiopulmonary exercise performance and resting/exercise hemodynamics, including maximum uptake of oxygen, maximal heart rate, forced vital capacity, forced expiratory volume in 1 second, oxygen saturations at maximal exercise, and right ventricular ejection fractionsurrogate

Adult survivors of the Mustard procedure have subnormal exercise capacities, potentially driven by chronotropic incompetence, peripheral deconditioning, and impaired lung function.

Cite This Study

Hechter et al. (2001) conducted an observational in Adult survivors of the Mustard procedure (n=84). Mustard procedure vs. Healthy population was evaluated on Cardiopulmonary exercise performance and right ventricular ejection fraction. Adult survivors of the Mustard procedure demonstrated subnormal exercise capacities, including lower maximum oxygen uptake and maximal heart rate, compared to a healthy population.

synapsesocial.com/papers/6aabc681300de2807df783b1https://doi.org/10.1017/s104795110100052x

Topics

Echocardiography
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Long-term Functional Outcome of Patients Following the Mustard Procedure: The Next Decade of Follow-up2007 · 15 citations
  2. 2The long‐term functional outcome in Mustard patients study: Another decade of follow‐up2018 · 9 citations
  3. 3Cardiopulmonary adaptation at rest and during exercise 10 years after Mustard atrial repair for transposition of the great arteries.1988 · 44 citations
  4. 4Assessment of right ventricular function during supine bicycle exercise after Mustard's operation.1982 · 107 citations
  5. 5Failure of Stroke Volume Augmentation During Exercise and Dobutamine Stress Is Unrelated to Load-Independent Indexes of Right Ventricular Performance After the Mustard Operation2000 · 74 citations