Key result
Higher RBC linoleic acid linked to ~88% lower symptomatic carotid artery disease risk per SD.
Why the study?
The relationship between red blood cell fatty acid composition and symptomatic carotid artery disease in patients undergoing carotid endarterectomy was explored to understand dietary fatty acid impact on vascular health.
Is red blood cell linoleic acid status associated with symptomatic carotid artery disease in patients undergoing carotid endarterectomy?
Observational (n=45)
Is red blood cell linoleic acid status associated with symptomatic carotid artery disease in patients undergoing carotid endarterectomy?
Odds Ratio: 0.116 (95% CI 0.022–0.607)
p-value: p=0.011
Higher cell membrane levels of linoleic acid are inversely associated with symptomatic carotid artery disease, supporting a potential protective role of dietary linoleic acid in vascular health.
Supports hypothesis of linoleic acid protection; hypothesis-generating and should not yet change practice.
Background and Purpose: The red blood cell fatty acid composition objectively reflects the long-term dietary intake of several fatty acids. In patients undergoing carotid endarterectomy, we explored whether red blood cell status of selected fatty acids related to symptomatic carotid artery disease. Methods: We included patients with symptomatic (n=22) and asymptomatic (n=23) carotid artery disease. We determined all-C18:1 trans, linoleic acid (LA, C18:2n6), alpha-linolenic acid (C18:3n3), and the omega-3 index (sum of eicosapentaenoic [C20:5n3] and docosahexaenoic [C22:6n3] acids) in both red blood cells and carotid plaque phospholipids by gas-chromatography. Results: In a multivariate logistic regression analysis, we only observed a significant association for LA, whose red blood cell status was inversely related to symptomatic carotid artery disease (odds ratio, 0.116 [95% CI, 0.022–0.607], P =0.011, for each 1-SD increase). A similar result was observed for LA in carotid plaque phospholipids. Conclusions: Cell membrane enrichment in LA, which reflects its intake, was inversely related to symptomatic carotid disease. This increases evidence supporting a favorable role of dietary LA in vascular health.
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Lázaro et al. (2020) conducted an observational in Carotid artery disease (n=45). Red blood cell linoleic acid (LA) status was evaluated on Symptomatic carotid artery disease (OR 0.116, 95% CI 0.022-0.607, p=0.011). Higher red blood cell linoleic acid status was inversely associated with symptomatic carotid artery disease (OR 0.116; 95% CI 0.022-0.607; P=0.011 per 1-SD increase).
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