September 11, 1982BMJ
Low dietary intake of linoleic acid predisposes to myocardial infarction
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Why the study?
Does low dietary intake of linoleic acid predispose to myocardial infarction in men?
Population
64 men aged below 60, comprising 32 patients who had a myocardial infarction within the preceding five days…
Comparison
Low dietary intake of linoleic acid. vs Age-matched healthy controls.
Design
Case-control
Authors
Discussion
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Implication
Does not support changing dietary recommendations; hypothesis-generating for linoleic acid intake and MI risk.
Structured PICO
Does low dietary intake of linoleic acid predispose to myocardial infarction in men?
P
Population
64 men aged below 60, comprising 32 patients who had a myocardial infarction within the preceding five days (mean age 51.4 years) and 32 age-matched male controls free from heart disease (mean age 51.7 years).
I
Intervention
Low dietary intake of linoleic acid (assessed retrospectively via fatty acid composition of plasma triglycerides and red-cell membrane phosphatidyl choline).
C
Comparator
Age-matched healthy controls (representing normal/higher dietary intake of linoleic acid).
O
Outcome
Proportion of linoleic acid and other fatty acids in plasma triglycerides and red-cell membrane phosphatidyl choline.surrogate
Men with recent myocardial infarction have significantly lower proportions of linoleic acid in red-cell membranes, suggesting that low dietary intake of polyunsaturated fats may predispose to ischemic heart disease.
Limitations
- Plasma triglyceride fatty acid composition could have been influenced by acute changes following myocardial infarction or subsequent dietary changes.
Cite This Study
Simpson et al. (1982) studied this question.
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