Key result
High tumor grade and trunk location linked to worse survival in pediatric synovial sarcoma.
Why the study?
Synovial sarcoma is an aggressive tumor with late local recurrence and metastasis, and long-term outcomes and prognostic factors in pediatric patients are not well defined.
Does wide surgical excision improve survival and reduce recurrence in pediatric patients with synovial sarcoma compared to marginal or intralesional resections?
Population
13 patients with synovial sarcoma younger than 20 years at diagnosis
Comparison
Wide surgical resections or amputations vs marginal or intralesional resections
Design
Retrospective multicenter observational study
Follow-up
Minimum 10 years
Authors
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May aid prognostic counseling in pediatric synovial sarcoma; leaves open prospective validation of grade- and location-based stratification.
Observational (n=13)
Yes
Does wide surgical excision improve survival and reduce recurrence in pediatric patients with synovial sarcoma compared to marginal or intralesional resections?
In pediatric patients with synovial sarcoma, wide surgical excision is the intervention of choice to reduce local recurrence, and long-term follow-up of at least 10 years is necessary due to late recurrences.
Speth et al. (2011) conducted an observational in Synovial sarcoma (n=13). Tumor characteristics and surgical excision type was evaluated on 5- and 10-year survival rates. In pediatric patients with synovial sarcoma, 5- and 10-year survival rates were 77% and 61%, respectively, with high tumor grade and trunk location acting as adverse prognostic factors.
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