What question did this study set out to answer?

To evaluate the enzymatic effect of proteolytic fragments of activated Hageman factor (factor XII) on single-chain bovine factor VII.

October 1, 1977Blood

Activation of bovine factor VII by hageman factor fragments

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Authors

RRR RadcliffeYale University ABA BagdasarianUniversity of Pennsylvania RCR ColmanYale University

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Implication

Biochemical analysis demonstrates rapid cleavage and activation of factor VII by Hageman factor fragments, indicating intrinsic pathway activation directly primes extrinsic coagulation.

Key Points

To evaluate the enzymatic effect of proteolytic fragments of activated Hageman factor (factor XII) on single-chain bovine factor VII.
Assayed the cleavage of single-chain bovine factor VII following incubation with 30,000-dalton and 70,000-dalton factor XII fragments.
Characterized the amino-terminal sequence of the resulting factor VII cleavage products.
Hageman factor fragments catalyzed rapid proteolysis of single-chain factor VII into an active two-chain form.
Amino-terminal sequencing identified Ala-Asx-Gly- and Ile-Val-Gly- chains, matching the cleavage pattern produced by activated factor X.

Cite This Study

Radcliffe et al. (1977) studied this question.

synapsesocial.com/papers/6aabcc16300de2807df7858f https://doi.org/10.1182/blood.v50.4.611.bloodjournal504611

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Implication

Biochemical analysis demonstrates rapid cleavage and activation of factor VII by Hageman factor fragments, indicating intrinsic pathway activation directly primes extrinsic coagulation.

Activation of bovine factor VII by hageman factor fragments

Discussion

Member takes

Implication

Key Points

Cite This Study

Activation of bovine factor VII by hageman factor fragments

Discussion

Member takes

Implication

Key Points

Cite This Study

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