Key result
Aging linked to a ~47% reduction in cerebral microvessel noradrenaline levels in rats.
Why the study?
The effect of aging on noradrenaline content in cerebral microvessels and its potential impact on neural control of brain microcirculation was investigated.
Does aging reduce noradrenaline content in rat brain microvessels?
Does aging reduce noradrenaline content in rat brain microvessels?
Aging significantly reduces noradrenaline content in rat brain microvessels, which may indicate a deficiency in neural control of the microcirculation.
Answers are grounded in this paper and cite their sources.
May indicate age-related neural control deficits in cerebral microcirculation; hypothesis-generating for human cerebrovascular aging studies.
Microvessels were isolated by sucrose gradient centrifugation and molecular seiving from forebrains of aged and young adult male Sprague-Dawley rats. Determination of noradrenaline levels in preparations obtained from both groups of animals indicated that the level of NA in cerebral microvessels isolated from aged animals (120 /+- 28 pg NA/mg protein) was significantly reduced when compared with the corresponding value from control (young adult) animals (226 /+- 35 pg NA/mg protein). This decrease in NA may indicate a deficiency in the neural control of the microcirculation and predispose to metabolic and functional disturbances of brain tissue.
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Embree et al. (1981) studied Aging. Aging vs. Young adult rats was evaluated on Noradrenaline levels in cerebral microvessels. Aging was associated with a significant reduction in noradrenaline levels in cerebral microvessels of rats.
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