Key result
Review outlines how glycemia and AGEs alter endothelial adhesion and apoptosis in diabetic vascular complications.
Why the study?
Hyperglycemia is a key factor in diabetic vascular disease, initiating endothelial functional and morphological changes that contribute to disease development.
This review summarizes the mechanisms by which hyperglycemia and advanced glycation end products induce changes in endothelial adhesion molecules and apoptosis in diabetic vascular disease.
Answers are grounded in this paper and cite their sources.
May link hyperglycemia and AGEs to vasculopathy via adhesion molecules and apoptosis; leaves open targeted interventions.
Hyperglycemia is one of the most prominent factors associated with diabetic vascular disease, the development of which is initated by functional and morphological alterations of the endothelium. The review summarizes several issues of glycemia and advanced glycation end products induced changes concerning soluble as well as cell bound endothelial adhesion molecules, and further addresses the aspect of apoptosis in the light of diabetic vascular complications.
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S. Baumgartner-Parzer (1997) conducted a review in Diabetic vascular disease. Glycemia and advanced glycation end products was evaluated. This review summarizes the effects of glycemia and advanced glycation end products on endothelial adhesion molecules and apoptosis in the context of diabetic vascular complications.
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