Key result
BEST sensor pacing leads maintain proper function in 98% of patients at one year.
Why the study?
Peak endocardial acceleration (PEA) correlates with myocardial contractility and sympathetic activity, but clinical testing of the BEST DDDR pacemaker incorporating a PEA sensor was needed.
Does the BEST pacing lead measuring peak endocardial acceleration provide physiological control of pacing rate in patients requiring a pacemaker?
Population
105 patients implanted with dual chamber pacemaker Living-1 (Sorin)
Comparison
PEA signal behavior under physical and mental stress and daily activities
Design
International observational study with 24-hour PEA Holter recordings
Follow-up
Approximately 1 year
Authors
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Supports sensor-lead feasibility for rate response; leaves open outcome benefits versus standard leads in randomized trials.
Observational (n=105)
Yes
Does the BEST pacing lead measuring peak endocardial acceleration provide physiological control of pacing rate in patients requiring a pacemaker?
The BEST pacing lead with a peak endocardial acceleration sensor is safe to implant, functions reliably up to 1 year, and provides physiological pacing rate control.
Langenfeld et al. (1998) conducted an observational in Patients requiring a dual chamber pacemaker (n=105). Biomechanical Endocardial Sorin Transducer (BEST) sensor pacing lead was evaluated on Proper sensor function in the short- and long-term. The BEST sensor pacing lead functioned properly in 98% of patients up to 1 year, with peak endocardial acceleration closely correlating with heart rate during daily activities.
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