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October 11, 2016QJM

Primary adrenal lymphoma presented with major general symptoms and had a poor overall survival rate of 61.9% at 2 years despite polychemotherapy.

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Population

28 patients diagnosed with primary adrenal lymphoma between 1994 and 2014

Design

Cohort

Follow-up

2 years

Key result

Primary adrenal lymphoma presented with major general symptoms and had a poor overall survival rate of 61.9% at 2 years despite polychemotherapy.

Authors

CLCamille LaurentOCOlivier CasasnovasLMLaurent Martin

Discussion

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Member takes

Overview

Alerts clinicians to aggressive primary adrenal lymphoma course; leaves open optimal therapies pending prospective validation.

Study Design

Type

Observational (n=28)

Multicenter

Yes

Structured PICO

P
Population
28 patients diagnosed with primary adrenal lymphoma between 1994 and 2014 across five regions of eastern France.
O
Outcome
Clinical, biological and radiological features, treatment, and overall survival outcomeshard clinical

Primary adrenal lymphoma presents with major general symptoms and frequent bilateral involvement, carrying a poor prognosis despite polychemotherapy.

Limitations

  • Adrenal insufficiency was not systematically tested.
  • Preliminary results of MRI to distinguish between PAL and adrenocortical carcinoma should be confirmed.

Cite This Study

Laurent et al. (2016) conducted an observational in Primary adrenal lymphoma (n=28). Primary adrenal lymphoma was evaluated on Overall survival at 2 years. Primary adrenal lymphoma presented with major general symptoms and had a poor overall survival rate of 61.9% at 2 years despite polychemotherapy.

synapsesocial.com/papers/6aaca5b64df67298da93ceb0https://doi.org/10.1093/qjmed/hcw174
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Also Consider

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  1. 1Clinical spectrum of primary adrenal lymphoma: results of a multicenter cohort study2020 · 31 citations
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  3. 3Histopathological Experience of Primary Adrenal Lymphoma From Two Tertiary Hospitals2023 · 1 citations
  4. 4Primary Bilateral Adrenal Lymphoma Revealed by Adrenal Insufficiency: From Constitutional Symptoms to Crisis2026
  5. 5Severe hypercalcemia as the presenting manifestation of bilateral primary adrenal lymphoma2024