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June 19, 2020European Journal of EndocrinologyOpen Access

Isolated primary adrenal lymphoma was associated with significantly shorter progression-free survival compared to extra-adrenal involvement (HR 40.1; 95% CI 2.63-613.7; P=0.008).

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Why the study?

Primary adrenal lymphoma is a rare lymphoid malignancy with predominant adrenal manifestation and risk of adrenal insufficiency, and its clinical picture needed refinement.

Does isolated adrenal involvement compared to extra-adrenal involvement affect survival in patients with primary adrenal lymphoma?

Comparison

Isolated adrenal involvement (iPAL) vs additional extra-adrenal involvement (PAL+)

Design

Multicenter retrospective cohort study

Follow-up

Median 41.6 months

Key result

Isolated primary adrenal lymphoma was associated with significantly shorter progression-free survival compared to extra-adrenal involvement (HR 40.1; 95% CI 2.63-613.7; P=0.008).

Authors

FMFatemeh MajidiSMSamuela MartinoMKMustafa Kondakci

Discussion

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Member takes

Overview

May warrant cautious prognostic assessment in isolated primary adrenal lymphoma; leaves open need for prospective validation and tailored strategies.

Study Design

Type

Cohort (n=97)

Multicenter

Yes

Structured PICO

Does isolated adrenal involvement compared to extra-adrenal involvement affect survival in patients with primary adrenal lymphoma?

P
Population
97 patients with primary adrenal lymphoma from 14 centers in Europe, Canada, and the United States, followed for a median of 41.6 months.
C
Comparator
Isolated adrenal involvement (iPAL) vs extra-adrenal involvement (PAL+)
O
Outcome
Progression-free survival (PFS) and overall survival (OS)hard clinical

Main Result

Hazard Ratio: 40.1 (95% CI 2.63–613.7)

p-value: p=0.008

Limitations

  • Retrospective analysis
  • Endocrinological assessment was often inadequate

Cite This Study

Majidi et al. (2020) conducted a cohort in Primary adrenal lymphoma (PAL) (n=97). Isolated adrenal involvement (iPAL) vs. Extra-adrenal involvement (PAL+) was evaluated on Progression-free survival (PFS) (HR 40.1, 95% CI 2.63-613.7, p=0.008). Isolated primary adrenal lymphoma was associated with significantly shorter progression-free survival compared to extra-adrenal involvement (HR 40.1; 95% CI 2.63-613.7; P=0.008).

synapsesocial.com/papers/6a557f2ccae1d55e053ea90ehttps://doi.org/10.1530/eje-19-0506
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adrenal lymphoma: presentation, management and prognosis2016 · 73 citations
  2. 2Histopathological Experience of Primary Adrenal Lymphoma From Two Tertiary Hospitals2023 · 1 citations
  3. 3O-09 BILATERAL ADRENAL MASS AND ADRENAL INSUFFICIENCY CAUSED BY PRIMARY ADRENAL LYMPHOMA; A CASE REPORT2026
  4. 4Primary Bilateral Adrenal Lymphoma Revealed by Adrenal Insufficiency: From Constitutional Symptoms to Crisis2026
  5. 5Severe hypercalcemia as the presenting manifestation of bilateral primary adrenal lymphoma2024