Key result
Coxsackie virus B4 infection linked to acute transverse myelitis and rapid paraplegia in case report.
Why the study?
Acute transverse myelitis is a rare clinical manifestation of Coxsackie virus infection with limited reported cases, particularly caused by Coxsackie virus B4.
Case Report (n=1)
This case report highlights a rare instance of acute transverse myelitis caused by Coxsackie virus B4 infection, supported by CSF antibody titers and spinal MRI findings.
Answers are grounded in this paper and cite their sources.
May prompt Coxsackie B4 testing in acute transverse myelitis; leaves open questions on pathogenesis and management.
Acute transverse myelitis is a rare clinical manifestation of Coxsackie virus infection which cause acute and progressive debilitating illness associated with loss of spinal cord function in the affected patients. A 62 year-old female developed symptoms of rapidly progressive paraplegia with sensory loss. On spinal MRI, T2 sagittal image showed increased signal intensity with cord swelling at T11-L2 level and 8 folds or greater rise of Coxsackie virus B4 neutralizing antibody titers was observed in the CSF. There is only one previous report of acute transverse myelitis caused by Coxsackie virus B4 infection to our knowledge. The presence of specific viral antibody titers change in the CSF and a corresponding spinal cord lesion are sufficient to suggest a causal relationship between the virus and the illness. This article is a case report of an unusual acute transverse myelitis caused by Coxsackie virus B4 infection.
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Ku et al. (1998) conducted a case report in Acute transverse myelitis (n=1). Coxsackie virus B4 infection was evaluated on Clinical manifestation of rapidly progressive paraplegia with sensory loss and spinal MRI findings. A 62-year-old female developed acute transverse myelitis with rapidly progressive paraplegia and sensory loss caused by Coxsackie virus B4 infection, confirmed by MRI and CSF antibody titers.
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