Key result
LMWH and balloon pulmonary valvotomy resolve a large RA thrombus and reduce pressure gradient ~84%.
Why the study?
Trilogy of Fallot is a rare congenital heart disease that can lead to complications such as thrombus formation and paradoxical embolisms due to chronic hypoxia and right-to-left interatrial shunt.
Case Report (n=1)
Absolute Event Rate: 28% vs 180%
This case highlights the successful management of a rare presentation of Trilogy of Fallot complicated by a large right atrial thrombus using low molecular weight heparin and balloon pulmonary valvotomy.
Supports individualized management in rare Trilogy of Fallot with thrombus; leaves open need for prospective validation before wider adoption.
Trilogy of Fallot is a rare congenital heart disease consisting of pulmonary stenosis, right-to-left interatrial shunt, and right ventricular hypertrophy. It can lead to complications such as thrombus formation as a result of chronic hypoxia leading to erythrocytosis and hyperviscosity, and paradoxical embolisms due to the right-to-left interatrial shunt. This report illustrates a case of a young man who presented with cyanosis and right heart failure with a history of recurrent episodes of transient ischemic attacks. He was found to have Trilogy of Fallot with a large right atrial thrombus. He showed significant improvement following treatment with low molecular weight heparin and thereafter undergoing balloon pulmonary valvotomy.
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Barik et al. (2025) conducted a case report in Trilogy of Fallot with right atrial thrombus (n=1). Low molecular weight heparin and balloon pulmonary valvotomy was evaluated on Pulmonary transvalvular pressure gradient. Treatment with low molecular weight heparin and balloon pulmonary valvotomy successfully resolved a large right atrial thrombus and reduced the pulmonary transvalvular pressure gradient from 180 mmHg to 28 mmHg.
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