Key result
Orthophosphate salts reversibly increase high-voltage calcium current amplitude to ~80% during recovery from gadolinium blockade.
Why the study?
The mechanisms underlying incomplete recovery of high voltage-activated calcium current from gadolinium blockade in ventricular myocytes were unclear.
Does orthophosphate salt improve calcium current recovery from gadolinium blockade in isolated guinea-pig ventricular myocytes?
Comparison
Exposure to 330 microM orthophosphate salt vs incomplete recovery without orthophosphate
Design
Patch-clamp electrophysiology study
Authors
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No immediate clinical implications; leaves open whether phosphate modulates cardiac calcium currents in vivo.
Does orthophosphate salt improve calcium current recovery from gadolinium blockade in isolated guinea-pig ventricular myocytes?
Orthophosphate salts reversibly improve the partial recovery of high voltage-activated calcium currents from gadolinium blockade in guinea-pig ventricular myocytes.
Guennec et al. (1996) studied this question. Orthophosphate salts (NaH2PO4 or KH2PO4) vs. Incomplete recovery state from gadolinium blockade was evaluated on Recovery of high voltage-activated calcium current (ICa,L) amplitude. Exposure to 330 microM orthophosphate salts reversibly increased the amplitude of high voltage-activated calcium currents to 80% of initial values during incomplete recovery from gadolinium blockade.