Key result
Persistent AF in HF is associated with ~27% less activity and increased night heart rate.
Why the study?
The incidence of atrial fibrillation and its temporal relationship with heart failure in patients indicated for cardiac resynchronization therapy were not well characterized.
Does persistent atrial fibrillation worsen heart rate variability, activity, and night heart rate in heart failure patients with biventricular pacemakers?
Cohort (n=410)
Does persistent atrial fibrillation worsen heart rate variability, activity, and night heart rate in heart failure patients with biventricular pacemakers?
Absolute Event Rate: 162% vs 221%
p-value: p=<0.0001
In heart failure patients with biventricular pacemakers, the onset of persistent atrial fibrillation is associated with a significant decrease in physical activity and heart rate variability, alongside an increase in night heart rate.
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May prompt closer device monitoring of activity and night heart rate in biventricular-paced HF patients; leaves open whether rhythm control improves outcomes.
Puglisi et al. (2008) conducted a cohort in Advanced heart failure (n=410). Persistent Atrial Fibrillation vs. Period before AF onset was evaluated on Patient activity (minutes) (p=<0.0001). Persistent atrial fibrillation in heart failure patients significantly decreased patient activity (from 221 to 162 minutes, P<0.0001) and increased night heart rate (from 68 to 94 bpm, P<0.0001).
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