Key result
High intraoperative FiO2 shows no benefit over low FiO2 for surgical site infections.
Why the study?
Controversy exists regarding the effects of a high versus a low intraoperative fraction of inspired oxygen in adults undergoing general anesthesia for non-cardiac surgery.
Does a high intraoperative fraction of inspired oxygen reduce surgical site infections in adults undergoing general anesthesia for non-cardiac surgery?
Population
Adults undergoing general anesthesia for non-cardiac surgery in 25 randomized clinical trials
Comparison
High (mostly 80%) versus low (mostly 30%) intraoperative fraction of inspired oxygen
Design
Systematic review and meta-analysis of randomized clinical trials
Authors
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High FiO2 confers no benefit on SSI, mortality, or stay after non-cardiac surgery; challenges WHO guidance while low-certainty evidence leaves optimal FiO2 unresolved.
Meta-Analysis
Does a high intraoperative fraction of inspired oxygen reduce surgical site infections in adults undergoing general anesthesia for non-cardiac surgery?
Odds Ratio: 0.91 (95% CI 0.81–1.02)
p-value: p=.10
In adults undergoing general anesthesia for non-cardiac surgery, a high intraoperative fraction of inspired oxygen does not significantly improve surgical site infections, mortality, or length of stay compared to a low fraction.
Høybye et al. (2022) conducted a meta-analysis in Non-cardiac surgery under general anesthesia. High fraction of inspired oxygen (FiO2) vs. Low FiO2 (mostly 30%) was evaluated on Surgical site infections (OR 0.91, 95% CI 0.81-1.02, p=.10). High intraoperative FiO2 did not significantly reduce surgical site infections compared to low FiO2 in adults undergoing non-cardiac surgery (OR 0.91; 95% CI 0.81-1.02; p=0.10).
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