Key result
Idiopathic congestive cardiomyopathy is not linked to specific T lymphocyte function defects.
Why the study?
The role of suppressor T lymphocyte function in patients with idiopathic congestive cardiomyopathy compared to heart failure from ischaemic heart disease and normal subjects was unclear.
Is suppressor T lymphocyte function altered in patients with idiopathic congestive cardiomyopathy compared to those with ischaemic heart failure and normal subjects?
Population
11 patients with idiopathic congestive cardiomyopathy, 11 age and sex matched patients with ischaemic heart failure, 11 normal subjects
Comparison
Idiopathic congestive cardiomyopathy vs ischaemic heart failure vs normal controls
Design
Observational study
Authors
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Nonspecific, nonsignificant reduction with wide variability in heart failure; leaves open any distinct role in cardiomyopathy.
Observational (n=33)
Is suppressor T lymphocyte function altered in patients with idiopathic congestive cardiomyopathy compared to those with ischaemic heart failure and normal subjects?
Suppressor T lymphocyte function is not specifically defective in idiopathic congestive cardiomyopathy, but may be non-specifically reduced in heart failure generally.
Lowry et al. (1987) conducted an observational in Idiopathic congestive cardiomyopathy (n=33). Idiopathic congestive cardiomyopathy vs. Ischaemic heart disease and normal subjects was evaluated on Suppressor T lymphocyte function. Idiopathic congestive cardiomyopathy was not associated with a specific defect in T lymphocyte function, though heart failure in general showed a non-significant reduction in suppressor function.
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