Key result
IV 2-acetyl-amino-1,3,4-thiadiazole-5-sulfonamide causes hyperventilation, increased A-a Po2, decreased Pco2, and acidosis in dogs.
Why the study?
The respiratory effects of carbonic anhydrase inhibition in trained unanesthetized dogs were investigated to understand its impact on ventilation and blood gas parameters.
Does a single intravenous injection of 2-acetyl-amino-1,3,4-thiadiazole-5-sulfonamide alter pulmonary ventilation and blood gas tensions in trained unanesthetized dogs?
Population
Trained unanesthetized dogs
Comparison
Before and after single intravenous injection of carbonic anhydrase inhibitor
Design
Experimental study
Authors
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May inform mechanisms of carbonic anhydrase inhibition; leaves open translation to human respiratory or acid-base management.
Does a single intravenous injection of 2-acetyl-amino-1,3,4-thiadiazole-5-sulfonamide alter pulmonary ventilation and blood gas tensions in trained unanesthetized dogs?
Carbonic anhydrase inhibition in dogs induces hyperventilation, altered blood gas tensions, and acidosis likely due to CO2 retention and urinary cation loss.
Carter et al. (1958) studied this question. 2-acetyl-amino-1,3,4-thiadiazole-5-sulfonamide was evaluated on pulmonary ventilation, alveolar gas exchange, arterial blood gas tensions and arterial blood pH. Intravenous injection of 2-acetyl-amino-1,3,4-thiadiazole-5-sulfonamide in dogs produced hyperventilation, increased alveolar-arterial Po2, decreased alveolar Pco2, and acidosis.
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