Key result
Pulse methylprednisolone yields good neurological recovery in a child with dengue-induced acute necrotizing encephalopathy.
Why the study?
Acute necrotizing encephalopathy of childhood (ANEC) is a rare complication of viral febrile illness with poor prognosis, and its association with dengue infection is uncommon.
Case Report (n=1)
Reports a rare case of acute necrotizing encephalopathy of childhood associated with dengue infection that showed good neurological recovery with steroid therapy.
May support steroids in rare dengue ANE; leaves open need for controlled pediatric trials.
Acute necrotizing encephalopathy of childhood (ANEC) is a clinico-radiological diagnosis characterized by acute onset, and progressive febrile encephalopathy preceded by viral-associated febrile illness and carries a very poor prognosis. We present a case of 9-year-old child with dengue virus-induced necrotizing encephalopathy who was managed with pulse methylprednisolone therapy followed by oral prednisolone. The rarity of ANEC in association with dengue and good neurological recovery with supportive treatment made us to report this case.
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Dar et al. (2023) conducted a case report in Acute necrotizing encephalopathy of childhood (ANEC) associated with dengue infection (n=1). Pulse methylprednisolone therapy followed by oral prednisolone was evaluated on Neurological recovery. Pulse methylprednisolone therapy followed by oral prednisolone resulted in good neurological recovery in a 9-year-old child with dengue virus-induced acute necrotizing encephalopathy.
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