Key result
Alzheimer's disease linked to higher flotillin-1-positive granular body density, with ~76% of these neurones containing tangles.
Why the study?
The distribution and accumulation of flotillin-1 in brain regions affected by Alzheimer's disease and its relationship to neurofibrillary tangles were not well characterized.
Case-Control (n=19)
Flotillin-1, a marker of lipid rafts, accumulates in lysosomes of tangle-bearing neurons in Alzheimer's disease.
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Flotillin-1 labelling shows no NFT correlation in AD; hypothesis-generating in small cohort and leaves open lipid-raft role pending larger studies.
Girardot et al. (2003) conducted a case-control in Alzheimer's disease (n=19). Alzheimer's disease vs. Controls was evaluated on Density of neuronal profiles containing large granular bodies. Alzheimer's disease cases had a significantly higher density of flotillin-1-positive granular bodies, with 76% of flotillin-1-positive neurones containing a neurofibrillary tangle.
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