Key result
Stopping anti-parkinsonian medication before DBS surgery is linked to neuroleptic malignant syndrome.
Case Report (n=1)
No
Discontinuation of anti-parkinsonian drugs prior to deep brain stimulation surgery can precipitate neuroleptic malignant syndrome, requiring high clinical suspicion for timely diagnosis and management.
BACKGROUND: The neuroleptic malignant syndrome is an uncommon but dangerous complication characterized by hyperthermia, autonomic dysfunction, altered mental state, hemodynamic dysregulation, elevated serum creatine kinase, and rigor. It is most often caused by an adverse reaction to anti-psychotic drugs or abrupt discontinuation of neuroleptic or anti-parkinsonian agents. To the best of our knowledge, it has never been reported following the common practice of discontinuation of anti-parkinsonian drugs during the pre-operative preparation for deep brain stimulation surgery for Parkinson's disease. CASE PRESENTATION: We present the first case of neuroleptic malignant syndrome associated with discontinuation of anti-parkinsonian medication prior to deep brain stimulation surgery in a 54-year-old Caucasian man. CONCLUSION: The characteristic neuroleptic malignant syndrome symptoms can be attributed to other, more common causes associated with deep brain stimulation treatment for Parkinson's disease, thus requiring a high index of clinical suspicion to timely establish the correct diagnosis. As more centers become eligible to perform deep brain stimulation, neurologists and neurosurgeons alike should be aware of this potentially fatal complication. Timely activation of the deep brain stimulation system may be important in accelerating the patient's recovery.
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Themistocleous et al. (2011) conducted a case report in Parkinson's disease (n=1). Discontinuation of anti-parkinsonian medication prior to deep brain stimulation surgery was evaluated on Development of neuroleptic malignant syndrome. Discontinuation of anti-parkinsonian medication prior to deep brain stimulation surgery can induce neuroleptic malignant syndrome, requiring high clinical suspicion for timely diagnosis.
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