Cytomegalovirus colitis in immunocompetent patients

reveal any abnormalities including anti-human immunodeficiency virus antibodies.What is the diagnosis of the ulcerative lesion in the colon?Answer to the Images: Cytomegalovirus Colitis Biopsy specimens were taken from the ulcerative lesions.Histopathological examination revealed atrophied crypts with cytomegalovirus inclusion bodies (Fig. C, H&E, ×200).The nucleus and cytoplasm of cells observed in the infected crypts were noted to be hypertrophied (Fig. D, H&E, ×400).Immunochemical examination showed positive nuclear staining for cytomegalovirus in an infected crypt (Figs E [×100] and F [×400], immunohistochemical staining).Question: A 63-year-old woman presented with left-sided abdominal pain and hematochezia noted over a week prior to hospitalization.She had been using antihypertensive medicine and did not report any other significant medical difficulties.A screening colonoscopic examination performed a year prior to presentation had been unremarkable.Abdominal CT showed segmental wall thickening with decreased enhancement of the proximal descending colon in addition to pericolic fat infiltration (Fig. A).Colonoscopic examination performed at Chungnam National University Hospital showed diffuse erythematous friable ulcerations located approximately 35 to 30 cm above the anal verge, and a biopsy was performed (Fig. B).Laboratory studies did not