Key result
African hypertensive patients show similar baroreceptor reflex sensitivity depression compared to European patients.
Why the study?
It is not known if baroreceptor function is depressed in African hypertensives to the same extent as in white Europeans.
Is baroreceptor reflex sensitivity depressed in black African hypertensive patients to the same extent as in white European hypertensive patients?
Observational (n=19)
No
Is baroreceptor reflex sensitivity depressed in black African hypertensive patients to the same extent as in white European hypertensive patients?
African hypertensive patients exhibit a depression of baroreflex sensitivity that is similar in magnitude to that seen in European hypertensive patients.
Comparable baroreflex depression in African hypertensives; extends European data but leaves open ethnicity-specific management implications.
Hypertension in the black African differs in some respects from white Europeans: complications due to accelerated atherosclerosis are rare and treatment with beta-blockers alone is ineffective. It is not known if baroreceptor function is depressed in African hypertensives to the same extent as it is in whites. Therefore, we have assessed baroreceptor reflex sensitivity (BRS) by the phenylephrine method in 19 African hypertensive patients living in the Gambia, West Africa. The results were compared to predicted BRS values for white patients of the same age and blood pressure calculated from a regression equation derived from 61 hypertensive patients studied in Oxford. It was found that baroreceptor reflex sensitivity was reduced in the African hypertensives and the log mean BRS was similar to the predicted value for Europeans of the same age and level of blood pressure (0.473 +/- 0.24 msec/mmHg and 0.489 +/- 0.21 msec/mmHg respectively). The resting mean arterial pressure in the African patients varied from 117 to 194 mmHg. The results indicated that African hypertensives have a depression of baroreflex sensitivity which is similar to European hypertensive patients.
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Sanderson et al. (1983) conducted an observational in Hypertension (n=19). Black African descent vs. White European descent (predicted values) was evaluated on Baroreceptor reflex sensitivity (log mean BRS). Baroreceptor reflex sensitivity in African hypertensive patients (0.473 msec/mmHg) was depressed to a similar extent as predicted values for European hypertensive patients (0.489 msec/mmHg).
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