Key result
LGE on CMR predicts ~6-fold higher mortality and HF hospitalization in idiopathic restrictive heart disease.
Why the study?
The prognostic value of cardiac magnetic resonance imaging parameters, including myocardial strain and late gadolinium enhancement, in idiopathic restrictive cardiomyopathy remains underexplored.
Do cardiac magnetic resonance imaging parameters (GLS and LGE) predict mortality and heart failure hospitalization in patients with idiopathic restrictive cardiomyopathy?
Cohort (n=100)
No
Do cardiac magnetic resonance imaging parameters (GLS and LGE) predict mortality and heart failure hospitalization in patients with idiopathic restrictive cardiomyopathy?
Odds Ratio: 6.34 (95% CI 1.77–22.71)
p-value: p=0.004
In patients with idiopathic restrictive cardiomyopathy, CMR-derived global longitudinal strain and late gadolinium enhancement are strong independent predictors of mortality and heart failure hospitalization.
LGE on CMR may aid risk stratification in idiopathic restrictive cardiomyopathy; leaves open prospective validation before guiding care.
BACKGROUND: Restrictive cardiomyopathy (RCM) is characterized by increased myocardial stiffness, impaired diastolic filling, and preserved systolic function until advanced stages. Cardiac magnetic resonance imaging (CMR) provides precise strain analysis and tissue characterization, yet its prognostic value in idiopathic RCM remains underexplored. This study aims to evaluate the prognostic significance of CMR parameters, particularly myocardial strain and late gadolinium enhancement (LGE), in predicting outcomes in patients with idiopathic RCM. RESULTS: Patients demonstrated moderately impaired strain values, with global longitudinal strain (GLS) measured at -10.59 ± 4.64% and global circumferential strain (GCS) at -14.50 ± 4.98%, while maintaining preserved biventricular ejection fractions. LGE was present in 40% of patients. A GLS value greater than -9.5% independently predicted mortality (odds ratio [OR]: 1.195, p = 0.044) and heart failure (HF) hospitalization (OR: 1.152, p = 0.013). Additionally, LGE emerged as a strong independent predictor of both mortality (OR: 6.340, p = 0.004) and HF hospitalization (OR: 4.654, p = 0.001). CONCLUSIONS: CMR is a valuable tool for prognostication in idiopathic RCM. GLS and LGE are independent predictors of adverse outcomes.
No takes yet. Share an insight, caveat, or question.
Asfour et al. (2025) conducted a cohort in Idiopathic restrictive heart disease (n=100). Late gadolinium enhancement (LGE) vs. Absence of LGE was evaluated on Mortality (OR 6.340, 95% CI 1.770-22.710, p=0.004). In patients with idiopathic restrictive heart disease, the presence of late gadolinium enhancement on cardiac MRI independently predicted mortality (OR 6.340) and heart failure hospitalization.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: