Key result
Zinc sulfate applied to the olfactory mucosa protects monkeys against poliomyelitis virus.
Why the study?
Chemical agents applied to the olfactory mucosa of monkeys have shown considerable protection against poliomyelitis virus, suggesting potential for human prophylaxis during outbreaks.
Does the application of chemical agents like 1% zinc sulfate to the olfactory mucosa protect against poliomyelitis infection?
Does the application of chemical agents like 1% zinc sulfate to the olfactory mucosa protect against poliomyelitis infection?
The authors propose devising a method for applying chemical prophylaxis (such as 1% zinc sulfate) to the olfactory mucosa to protect against poliomyelitis.
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Should not alter clinical practice; leaves open the need for human trials of zinc sulfate prophylaxis against poliomyelitis.
Lee Shahinian (1938) studied Poliomyelitis. 1 per cent zinc sulfate was evaluated. Application of 1% zinc sulfate to the olfactory mucosa confers resistance against poliomyelitis virus in monkeys, suggesting it may deserve a prophylactic trial in humans.
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