Key result
Porcine pulmonary xenografts provide the most useful alternative to homografts for post-Ross RVOT reconstruction.
Why the study?
The increasing shortage of pulmonary homografts necessitates consideration of alternative options for right ventricular outflow tract reconstruction.
What are the alternative options for right ventricular outflow tract reconstruction given the shortage of pulmonary homografts?
What are the alternative options for right ventricular outflow tract reconstruction given the shortage of pulmonary homografts?
Porcine pulmonary xenografts provide a commercially available and acceptable alternative for right ventricular outflow tract reconstruction amid the increasing shortage of pulmonary homografts.
Porcine pulmonary xenografts may address homograft shortages for post-Ross RVOT reconstruction; leaves open need for prospective durability data.
The popularity of the Ross operation has drawn attention to the need for a satisfactory replacement of the excised pulmonary valve and artery. Although living autogenous tissue is desirable, it has not been possible to manufacture a satisfactory living conduit, and pulmonary homografts have provided a satisfactory long-term solution. Now, with the increasing shortage of homografts, a number of alternative options have to be considered. The most useful and readily acceptable replacement is a porcine pulmonary xenograft, which is now commercially available. Other prospects for future consideration relate to the use of transgenic pig tissue and developing techniques of tissue engineering. In emergency conditions where a valve conduit is unavailable, a temporary solution is to use a simple tube of autogenous pericardium.
No takes yet. Share an insight, caveat, or question.
Donald N. Ross (2010) conducted a review in Right Ventricular Outflow Tract Reconstruction. Right ventricular outflow tract reconstruction options was evaluated. Porcine pulmonary xenografts are the most useful and readily acceptable alternative to pulmonary homografts for right ventricular outflow tract reconstruction following the Ross operation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: