Key result
Roasted GRP extract improves glucose tolerance vs raw extract in diabetic mice by enhancing insulinotropic action.
Why the study?
Roasting Glycyrrhizae Radix may modify its anti-diabetic action due to compositional changes, but the effects and mechanisms were unclear.
Does roasted Glycyrrhizae Radix (GRP) improve anti-diabetic action compared to raw Glycyrrhizae Radix (GR) in diabetic mice and cell models?
Does roasted Glycyrrhizae Radix (GRP) improve anti-diabetic action compared to raw Glycyrrhizae Radix (GR) in diabetic mice and cell models?
Roasted Glycyrrhizae Radix (GRP) demonstrates superior anti-diabetic properties compared to raw extract by enhancing insulinotropic action through its component glycyrrhetinic acid.
GRP may enhance insulin secretion in diabetic mice; hypothesis-generating and requires human trials before any clinical consideration.
We hypothesized that roasted Glycyrrhizae Radix (Glycyrrhizin Radix Praeparata, GRP) might modify anti-diabetic action due to compositional changes. Then we examined the anti-diabetic effect and mechanism of raw Glycyrrhizae Radix (GR) and GRP extracts and their major respective components, glycyrrhizin and glycyrrhetinic acid. In partial pancreatectomized (Px) diabetic mice, both GR and GRP improved glucose tolerance, but only GRP enhanced glucose-stimulated insulin secretion as much as exendin-4. Both GR and GRP extracts enhanced insulin-stimulated glucose uptake through peroxisome proliferation-activated receptor (PPAR)-gamma activation in 3T3-L1 adipocytes. Consistently with the results of the mice study, only GRP and glycyrrhetinic acid enhanced glucose-stimulated insulin secretion in isolated islets. In addition, they induced mRNA levels of insulin receptor substrate-2, pancreas duodenum homeobox-1, and glucokinase in the islets, which contributed to improving beta-cell viability. In conclusion, GRP extract containing glycyrrhetinic acid improved glucose tolerance better than GR extract by enhancing insulinotropic action. Thus, GRP had better anti-diabetic action than GR.
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Ko et al. (2007) studied Diabetes. Roasted Glycyrrhizae Radix (GRP) extract vs. Raw Glycyrrhizae Radix (GR) extract was evaluated on Glucose tolerance and glucose-stimulated insulin secretion. Roasted Glycyrrhizae Radix (GRP) extract containing glycyrrhetinic acid improved glucose tolerance better than raw extract by enhancing insulinotropic action in diabetic mice.
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