Key result
Pulmonary resection of adrenal cortical carcinoma metastases is linked to ~71% 5-year survival versus no resection.
Why the study?
Data concerning the treatment of pulmonary metastases from adrenal cortical carcinoma are sparse.
Does pulmonary resection improve survival in patients with pulmonary metastases from adrenal cortical carcinoma?
Cohort (n=24)
No
Does pulmonary resection improve survival in patients with pulmonary metastases from adrenal cortical carcinoma?
Pulmonary resection of metastases from adrenal cortical carcinoma is associated with significantly prolonged survival compared to non-surgical management.
Answers are grounded in this paper and cite their sources.
May support resection in selected patients with resectable metastases; hypothesis-generating and requires prospective validation.
Adrenal cortical carcinoma is uncommon. There is little controversy concerning treatment of the primary tumor. However, data concerning the treatment of pulmonary metastases are sparse. In order to assess the results of therapy, we reviewed our 14-year experience. Records of 24 patients admitted to our institution from 1973 to 1991 with the diagnosis of adrenal cortical carcinoma and pulmonary metastases were reviewed. Ten patients underwent pulmonary resection, 12 received chemotherapy, and 2 no therapy. In the pulmonary resection group, treatment consisted of wedge resection in 8 patients and lobectomy in 2. For the 10 patients undergoing resection of their pulmonary metastases, the 5-year survival was 71% (median not reached at 5 years). This was significantly longer than those not resected, with no one alive at 3 years (median survival 11 months). Our data suggest that those patients who are able to have their pulmonary metastases resected survive significantly longer than those who do not.
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Kwauk et al. (1993) conducted a cohort in Adrenal cortical carcinoma with pulmonary metastases (n=24). Pulmonary resection vs. No resection (chemotherapy or no therapy) was evaluated on 5-year survival. Pulmonary resection of metastases from adrenal cortical carcinoma was associated with a 71% 5-year survival, longer than those not resected.
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