Key result
Norovirus P2 domain differences segregate unrelated outbreaks while complete conservation tracks single-outbreak strains.
Why the study?
Differences within the P2 domain of norovirus genogroup I strains may help distinguish unrelated outbreaks and track strains from a common source.
Genetic characterization of the P2 domain in norovirus genogroup I can effectively differentiate between related and unrelated outbreaks.
May aid norovirus outbreak tracking via P2 sequencing; leaves open prospective validation before routine use.
In this study, we demonstrate that differences within the P2 domain of norovirus genogroup I (GI) strains can be used to segregate outbreaks which are unrelated, whereas complete conservation within this region allows tracking of strains that are part of a single outbreak and likely to have a common source.
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Xerry et al. (2010) studied this question. Differences within the P2 domain of norovirus genogroup I strains can segregate unrelated outbreaks, while complete conservation allows tracking of strains from a single outbreak.
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