Key result
Successful CTO recanalization is linked to a ~24% increase in CFVR at five months.
Why the study?
The potential for recovery of impaired microvascular function in collateral dependent myocardium after recanalisation of a chronic total coronary occlusion and its determinants were not well characterized.
Does successful recanalisation of a chronic total coronary occlusion improve microvascular function in collateral dependent myocardium?
Population
120 patients after successful recanalisation of chronic total coronary occlusion
Comparison
Microvascular function after recanalisation and at follow up
Design
Cohort study
Follow-up
Mean 5.0 months
Authors
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Post-CTO recanalization microvascular dysfunction often improves without impeding LV recovery; leaves open diabetes-targeted strategies in persistent cases.
Cohort (n=120)
Does successful recanalisation of a chronic total coronary occlusion improve microvascular function in collateral dependent myocardium?
Absolute Event Rate: 2.5% vs 2.01%
p-value: p=<0.001
Microvascular dysfunction after CTO recanalisation is frequently transient, does not impede LV function recovery, and is strongly influenced by the presence of diabetes mellitus.
Gerald S. Werner (2004) conducted a cohort in Chronic total coronary occlusion (n=120). Successful recanalisation vs. Baseline (pre-follow-up) was evaluated on Coronary flow velocity reserve (CFVR) (p=<0.001). Successful recanalisation of chronic total coronary occlusion significantly improved coronary flow velocity reserve from 2.01 at baseline to 2.50 at 5 months (p<0.001).
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