Key result
SAPW ECG detects abnormal atrial vulnerability in unexplained stroke with ~88% negative predictive value.
Why the study?
Does signal-averaged P wave ECG correlate with electrophysiological testing for detecting atrial vulnerability in patients with unexplained ischemic strokes?
Population
20 patients with unexplained ischemic strokes
Comparison
Signal-averaged P wave (SAPW) ECG vs Electrophysiological studies to determine atrial…
Design
Cross-sectional
Authors
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May identify atrial vulnerability via SAPW in cryptogenic stroke; hypothesis-generating and requires prospective validation before any clinical role.
Observational (n=20)
Does signal-averaged P wave ECG correlate with electrophysiological testing for detecting atrial vulnerability in patients with unexplained ischemic strokes?
Absolute Event Rate: 142% vs 120%
p-value: p=0.03
Signal-averaged P wave ECG may be a useful non-invasive tool to identify patients with unexplained stroke at risk of paroxysmal atrial fibrillation who warrant electrophysiological testing.
Gencel et al. (1994) conducted an observational in Unexplained ischemic strokes (n=20). Abnormal atrial vulnerability at electrophysiological study (Group I) vs. Normal atrial vulnerability (Group II) was evaluated on Filtered P wave duration (msec) (p=0.03). Signal-averaged P wave ECG parameters (duration >125 msec and RMS 30 <3 microV) detected abnormal atrial vulnerability with 78% positive and 88% negative predictive value in unexplained stroke.
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