Key result
Diabetes links to ~9% higher risk of 30-day death or HF readmission after hospitalization.
Why the study?
Do diabetes and severe renal dysfunction predict 30-day death or heart failure readmission in adults after a first heart failure hospitalization?
Cohort (n=31,369)
Do diabetes and severe renal dysfunction predict 30-day death or heart failure readmission in adults after a first heart failure hospitalization?
Odds Ratio: 1.09 (95% CI 1.03–1.16)
Absolute Event Rate: 20.5% vs 18.8%
Diabetes and severe renal dysfunction are independent predictors of 30-day death or heart failure readmission following a first heart failure hospitalization, supporting the need for cardiorenal risk assessment before discharge.
Supports closer post-discharge monitoring in diabetic HF patients; hypothesis-generating and should not yet change practice.
Background Diabetes is a key cardiometabolic driver of heart failure morbidity and commonly coexists with renal dysfunction. Identifying diabetes-related cardiorenal risk before discharge may improve post-hospital risk stratification. Objective To evaluate associations of diabetes and severe renal dysfunction with 30-day death or heart failure readmission after heart failure hospitalization. Methods We performed a retrospective cohort study using MIMIC-IV v3.1. Adults with a first qualifying heart failure hospitalization were included. Diabetes was identified using diagnosis codes. Severe renal dysfunction was defined as creatinine ≥2.0 mg/dL within 24 hours of admission. The primary outcome was all-cause death or heart failure readmission within 30 days. Logistic regression adjusted for age, sex, diabetes, and severe renal dysfunction. Results Among 31,369 first heart failure hospitalizations, 13,920 patients (44.4%) had diabetes. Creatinine was available in 28,637 patients (91.3%), and 5,499 (17.5%) had severe renal dysfunction. The overall 30-day event rate was 19.6%. Events were more common in patients with diabetes than without diabetes (20.5% vs 18.8%), driven by higher heart failure readmission (14.8% vs 11.7%). Diabetes remained independently associated with 30-day events after adjustment for severe renal dysfunction (adjusted odds ratio [OR] 1.09, 95% confidence interval [CI] 1.03-1.16). Severe renal dysfunction was a stronger independent predictor (adjusted OR 1.55, 95% CI 1.44-1.66). Conclusions Diabetes was common and independently associated with early adverse outcomes after heart failure hospitalization. Severe renal dysfunction amplified risk, supporting diabetes-focused cardiorenal risk assessment before discharge. Is this an encore abstract? No
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Moseley et al. (2026) conducted a cohort in Heart failure (n=31,369). Diabetes vs. No diabetes was evaluated on All-cause death or heart failure readmission within 30 days (OR 1.09, 95% CI 1.03-1.16). Diabetes was independently associated with a higher risk of 30-day all-cause death or heart failure readmission following heart failure hospitalization (OR 1.09; 95% CI 1.03-1.16).
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