Key result
Intensive risk factor management improves both vWF and FMD, which are inversely correlated.
Why the study?
The relationship between flow-mediated dilatation and von Willebrand factor as measures of endothelial function, their association with 10-year cardiovascular risk, and their response to intensive risk factor management are unclear.
Does intensive cardiovascular risk factor management improve endothelial function markers (FMD and vWF) in hypertensive patients, and do these markers correlate with each other and cardiovascular risk?
Population
132 subjects including 89 hypertensive and 43 healthy normotensive individuals
Comparison
Baseline measurements vs after 6 months of intensive cardiovascular risk factor management
Design
Observational cohort study
Follow-up
6 months
Authors
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FMD and vWF track endothelial function and Framingham risk in hypertension; supports complementary biomarker use but leaves prognostic value and practice change open.
Observational (n=132)
Does intensive cardiovascular risk factor management improve endothelial function markers (FMD and vWF) in hypertensive patients, and do these markers correlate with each other and cardiovascular risk?
Effect estimate: r = -0.517
p-value: p=<0.001
Flow-mediated dilatation and von Willebrand factor are inversely correlated markers of endothelial function that both improve with intensive cardiovascular risk factor management in hypertensive patients.
Felmeden et al. (2003) conducted an observational in Hypertension (n=132). Intensive cardiovascular risk factor management vs. Baseline was evaluated on Correlation between von Willebrand factor (vWF) and flow-mediated dilatation (FMD) (r = -0.517, p=<0.001). Plasma von Willebrand factor and flow-mediated dilatation correlated significantly (r = -0.517, P<0.001) and both improved after 6 months of intensive risk factor management (P<0.002).
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