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Demonstrates that dietary changes alter urinary MHPG levels in depressed individuals but not healthy controls, indicating potential metabolic sensitivity in depression.
The authors studied the effect of a catecholamine-controlled diet on the urinary level of 3-methoxy-4-hydroxyphenylglycol (MHPG) of 6 depressed patients and 6 normal volunteers. The normal subjects showed no change in MHPG levels on or off the diet; the depressed patients showed a significant increase in MHPG while off the diet.
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Muscettola et al. (1977) studied this question.
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